RNA Platforms
SYTE-cRNA Platform (Circular RNA)
A novel Circular RNA platform engineered for stability and enhanced protein expression.
Applications:
Prophylactic vaccines for infectious diseases, such as Dengue and Andes Virus, among others.
Therapeutics for diseases requiring robust and prolonged protein expression.
Key Features:
- Covalently Closed Structure: Free from 5’-cap and 3’-poly(A) tail, offering exceptional stability against exonucleases.
- Long-Lasting Expression: Enables sustained protein production with reduced immunogenicity compared to linear mRNA.
- Smaller Topological Size: Facilitates efficient encapsulation into delivery systems like lipid nanoparticles.
- Re-Dosable: Allows for multiple administrations without compromising safety or efficacy.
SYTE-Linear RNA Platform
A novel linear RNA platform engineered for stability and enhanced protein expression.
Applications:
Prophylactic vaccines for infectious diseases, such as Dengue and Andes Virus, among others.
Therapeutics for diseases requiring robust and redosable protein expression.
Key Features:
- Structured Ends: Free from 5’-cap and 3’-poly(A) tail, offering exceptional stability against exonucleases.
- High Expression: Enables sustained protein production using translation initiation sequence.
- Adequate Topological Size: Facilitates efficient encapsulation into delivery systems like lipid nanoparticles.
- Re-Dosable: Allows for multiple administrations without compromising safety or efficacy.
Advantages of non-viral Gene Therapies and Vaccines
Viral vectors
AdV
AAV
HSV
LV
- Complex Manufacturing and Scalability
- High Immunogenicity
- Limited Genetic Cargo Capacity
- Limited Repeated Dosing
- Complex Storage Conditions
- Challenging Design
DNA & RNA PLATFORMS
L-DNA
L-RNA
C-DNA
C-RNA
SMART-DNA
- Simplified Manufacturing and Scalability
- Enhanced Safety Profile
- Capacity for Larger Genetic Cargo
- Facilitated Repeated Dosing
- Improved Stability and Storage
- Rapid Design and Flexibility
