DNA Platforms

SYTE Linear DNA Platform (L- DNA)

A next-generation Linear DNA vector engineered for high efficiency, safety, and scalability.

Applications:

Gene therapy for rare genetic disorders, such as Dystrophic Epidermolysis Bullosa or others. Oncology immunotherapies, including Melanoma treatments.

Potential applications includes liver and retina diseases, among others.

Key Features:

Covalently Closed Ends: Hairpin loop structures protect against degradation by exonucleases.
Enhanced Nuclear Transport: Equipped with DNA Nuclear Transporting Sequences (DNTS) to improve nuclear entry by 40%.
Torsion-Free Design: Eliminates supercoiling, enabling better transgene delivery and expression.
Non-Viral, Non-Integrative: Minimizes risks of unwanted chromosomal integration.
Re-Dosable Therapy: Designed for flexible dosing to meet specific therapeutic needs.

SYTE Circular DNA Platform (C-DNA)

A minicircle DNA free of antibiotic resistance, in versions optimized for vaccines and short- and long-term therapies.

Applications:

Animal and human vaccines for infectious diseases.

Gene Therapy for different genetic and non-genetic disorders

Key Features:

Circular and supercoiled double-stranded DNA with stability to degradation by exonucleases.
Enhanced Nuclear Transport: Equipped with DNA Nuclear Transporting Sequences (DNTS) to improve nuclear entry by 40%.
Availability of different versions to express one or multiple genes of interest.
Availability of different versions to support the expression of the genes of interest in different periods of time.
Non-Viral, Non-Integrative: Minimizes risks of unwanted chromosomal integration.
Re-Dosable Therapy: Designed for flexible dosing to meet specific therapeutic needs.

SMART - DNA

Structured, modular, adaptive, responsive and targeted DNA is SYTE.bio’s next-generation linear double-stranded DNA molecule engineered for self-delivery without the need for external delivery systems.

This advanced DNA platform incorporates structural and functional innovations to maximize stability, safety, and therapeutic efficacy.

Applications:

Gene therapy for rare genetic disorders, such as Dystrophic Epidermolysis Bullosa or others. Oncology immunotherapies, including Melanoma treatments.

Potential applications includes liver and retina diseases, among others.

Advantages of SMART-DNA:

Self-Delivery: Eliminates the need for lipid nanoparticles, electroporation, or other delivery methods.
Safety: Non-viral, non-integrative design avoids risks of mutagenesis or immune rejection.
Scalability: Simplifies manufacturing and reduces costs, enabling broad accessibility.
Stability: Highly resistant to enzymatic degradation and capable of being freeze-dried for long-term storage.
Re-Dosable: Allows repeated administration to sustain therapeutic benefits.